Propacetamol is an orally active prodrug of Acetaminophen ( HY-66005 ), which exerts antipyretic and analgesic effects after metabolism. Propacetamol reduces Aspirin (ASA) ( HY-14654 )-induced elevation of malondialdehyde ( MDA ) in gastric mucosa and plasma, regulates the levels of gastric mucosal glutathione ( GSH and GSSG ) to maintain cellular antioxidant defense, and increases gastric mucosal uric acid ( UA ) levels. Propacetamol exerts a dose-dependent protective effect against ASA-induced gastric mucosal damage in rats. Propacetamol can be used for the study of gastric mucosal injury by interfering with oxidative stress.
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