βGlcCer

Overview

βGlcCer is a glycosphingolipid. βGlcCer directly increases the development and PKCα and PKCδ activation in mouse bone marrow-derived DCs (BMDCs). β-GlcCer accumulating in Gaucher disease activates microglia through macrophage-inducible C-type lectin (Mincle) to induce phagocytosis of living neurons, which exacerbates Gaucher symptoms.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Allergy | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Drug Derivative | Products > Signaling Pathways > PKC | Products > Signaling Pathways > C-type Lectin-like Receptors (CTLRs)

Product Information

• Catalog No.: HY-152940
• CAS No.: 887907-50-8
• Molecular Formula: C48H91NO8
• Molecular Weight: 810.26
• Purity: 99.98%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 1.25 mg/mL (1.54 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source