Bioactive compounds used in cancer, tumor and oncology research.
19-Oxocinobufotalin is capable of suppressing EMT (Epithelial-mesenchymal transition) and weakening the migratory...
β-NETA is a potent and noncompetitive choline acetyltransferase (ChA; IC 50 =76 μM) and cholinesterase (ChE; IC 50...
DCEM1 binds to heat shock protein 60 ( HSP60 ) and inhibits the interaction of HSP60 with ClpP , thereby blocking...
NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC 50 s of 2.3 μM, 12.5 μM, and...
MG28 exhibits a remarkable cytotoxic effect, which is the likely consequence of its direct and intense DNA damaging...
SOS1-IN-16 (Comp 54) is a selective inhibitor of SOS1 with an IC 50 of 7.2 nM. SOS1-IN-16 has inhibitory activity of...
FLT3-IN-4 is a potent and orally effective Fms-like tyrosine receptor kinase 3 ( FLT3 ; IC 50 =7 nM) inhibitor for...
HTH-01-015 is a selective NUAK1/ARK5 inhibitor ( IC 50 is 100 nM). HTH-01-015 inhibits NUAK1 with >100-fold higher...
MDK83190 is a potent apoptosis activator, induces Apaf-1 oligomerization, increases procaspase-9 processing and...
Monomethyl auristatin E intermediate-1 is an intermediate reagent in the synthesis of Monomethyl auristatin E (...
STING-IN-3 is an inhibitor of stimulator of interferon genes ( STING ) . STING-IN-3 efficiently inhibits both...
Bisindolylmaleimide I (GF109203X) hydrochloride is a cell-permeable and reversible PKC inhibitor ( IC 50 of 20 nM...
GRK6-IN-4 is a G protein coupled receptor 6 kinase ( GRK6 ) inhibitor with an IC 50 of 1.56 μM. GRK6-IN-4 can be...
LY-2584702 hydrochloride is a selective ATP competitive inhibitor of p70S6K with an IC 50 of 4 nM. In S6K1 enzyme...
LTβR-IN-1 (Compound 919278) is a potent, selective lymphotoxin β receptor (LTβR) inhibitor. LTβR-IN-1 also...
CDK2-IN-54 (Formula I) is a CDK2 inhibitor. CDK2-IN-54 can be used in cancer research such as triple-negative breast...
Idelalisib-d 5 is a deuterium labeled Idelalisib. Idelalisib is a highly selective and orally bioavailable p110δ...
Runx1-CBFβ interaction inhibitor 1 is an allosteric inhibitior of Runt domain-CBFb interaction (IC 50 =3.2 μM).
DTA (2,4-Disulfamyl-5-trifluoromethylaniline) is a cyclic AMP phosphodiesterase inhibitor that binds to erythrocyte...
KU004 is a potent dual EGFR/HER2 inhibitor with anticancer effects. KU004 inhibits the proliferation of human breast...
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