Butaprost free acid is a selective prostaglandin E receptor (EP2) agonist with an EC 50 of 33 nM and a K i of 2.4 μM for murine EP2 receptor. Butaprost free acid is less activity against murine EP1, EP3 and EP4 receptors. Butaprost free acid attenuates fibrosis by hampering TGF-β/Smad2 signalling.
Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Endocrinology | Products > Signaling Pathways > Prostaglandin Receptor | Products > Signaling Pathways > TGF-beta/Smad
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