AcylCoA:cholesterol acyltransferase ( ACAT ) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol .1 Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase with an IC 50 of 7 nM.2 When co-administered to rabbits or rats fed a high fat, high cholesterol diet, oleic acid-2,6-diisopropylanilide decreased low density lipoproteins and elevated high density lipoprotein levels when administered at 0.05%.
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