Volasertib (Standard)

Overview

Volasertib (Standard) is the analytical standard of Volasertib. This product is intended for research and analytical applications. Volasertib (BI 6727) is an orally active, highly potent and ATP-competitive Polo-like kinase 1 ( PLK1 ) inhibitor with an IC50 of 0.87 nM. Volasertib inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. Volasertib induces mitotic arrest and apoptosis . Volasertib, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Others | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Polo-like Kinase (PLK) | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Reference Standards

Product Information

• Catalog No.: HY-12137R
• CAS No.: 755038-65-4
• Molecular Formula: C34H50N8O3
• Molecular Weight: 618.81
• Purity: 98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source