Mocetinostat (MGCD0103) is a potent, orally active and isotype-selective HDAC (Class I/IV) inhibitor with IC 50 s of 0.15, 0.29, 1.66 and 0.59 μM for HDAC1 , HDAC2 , HDAC3 and HDAC11 , respectively. Mocetinostat shows no inhibition on HDAC4 , HDAC5 , HDAC6 , HDAC7 , or HDAC8 .
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