iGP-1

Overview

iGP-1 is a cell-permeable, selective mixed inhibitor of mitochondrial sn-glycerol-3-phosphate dehydrogenase ( mGPDH ), with IC 50 s of 6.3 μM and 13.6 μM for rat mGPDH activity and H 2 O 2 production, respectively. iGP-1 specifically blocks the mitochondrial component of the glycerophosphate shuttle without affecting cytosolic GPDH. iGP-1 not only inhibits cell proliferation and glutaminolysis, and enhances glycolysis , but also significantly alters key cellular physiological processes such as apoptosis , ROS production, HIF-1α stability and mitochondrial membrane potential. iGP-1 remains active in neutrophil cultures under both normoxic and hypoxic conditions, and serves as an ideal probe for glycerol-3-phosphate metabolic mechanisms. iGP-1 has been applied to studies on prostate cancer and related metabolic pathways.

Application

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Product Information

• Catalog No.: HY-121970
• CAS No.: 27031-00-1
• Molecular Formula: C17H15N3O3
• Molecular Weight: 309.32
• Purity: 99.43%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (8.08 mM); Clear solution
• Availability: In-stock

Source

Original product source