PPACK TFA is a potent, peptidic inhibitor targeting thrombin and granzyme GZMK . PPACK TFA specifically blocks the activities of thrombin and GZMK, thereby inhibiting thrombin-mediated PAR-1 cleavage, as well as downstream inflammatory and procoagulant signaling pathways. Through stabilizing IκB proteins, blocking NF-κB activation and reducing systemic levels of proinflammatory/procoagulant biomarkers, PPACK TFA exerts multiple effects including anti-inflammatory, antithrombotic, barrier repair, and inhibition of atherosclerotic plaque progression. PPACK TFA binds to platelets without interference from kininogen, effectively limiting acute thrombus growth and reducing eosinophil infiltration and goblet cell hyperplasia in asthma models. PPACK TFA is an important tool molecule for investigating the mechanisms of atherosclerosis, asthma and related thromboinflammatory diseases.
Products | Products > Disease Areas > Allergy | Products > Disease Areas > Chronic Disease and Inflammation | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Allergic Asthma | Products > Disease Areas > Atherosclerosis and Inflammation | Products > Disease Areas > Atherosclerosis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Protease Activated Receptor (PAR) | Products > Signaling Pathways > Thrombin | Products > Signaling Pathways > NF-κB
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