Surfen is a potent heparan sulfate antagonist. Surfen inhibits FGF2 binding and signal transduction. Surfen binds to glycosaminoglycans and reduces tau hyperphosphorylation. Surfen inhibits the activity of recombinant uronyl 2-O-sulfotransferase with an IC 50 of approximately 2 μM. Surfen inhibits HSV-1 viral infection . Surfen inhibits neural differentiation, delays remyelination, and alleviates EAE.
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