GSK699

CAS No.：2260944-68-9
Grade：98.80%
Formula：C45H51BrN8O7
M.W.：895.84

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

GSK699 is a KAT2A/ B/PCAF/GCN5 PROTAC degrader . GSK699 induces proteasome-dependent degradation of KAT2A , KAT2B , PCAF and GCN5 , regulates the histone acetyltransferase activity of the SAGA complex, and reduces the level of histone H3K9ac . GSK699 inhibits the growth of neuroblastoma, acute myeloid leukemia and small cell lung cancer cells. GSK699 reduces the production of inflammatory cytokines and chemokines, and impairs LPS-stimulated immune cell responses. GSK699 is applicable to research related to acute myeloid leukemia, small cell lung cancer , neuroblastoma and inflammatory diseases. (Pink: GCN5/PCAF ligand ( HY-101027 ); Blue: Cereblon ligand ( HY-103596 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Small Cell Lung Cancer | Products > Disease Areas > Acute Myeloid Leukemia | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > CXCR | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > CD28 | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Histone Acetyltransferase | Products > Signaling Pathways > Interleukin Related

Product Information

Catalog No.: HY-122822
CAS No.: 2260944-68-9
Molecular Formula: C45H51BrN8O7
Molecular Weight: 895.84
Purity: 98.80%
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Availability: In-stock

Source

Original product source

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