HA-1004

CAS No.：91742-10-8
Grade：99.04%
Formula：C12H15N5O2S
M.W.：293.34
Solvent：≥ 1.25 mg/mL (4.26 mM); Clear solution

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

HA-1004 is a selective inhibitor of PKA , which can inhibit lipolysis and induce vascular relaxation. HA-1004 is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 is an antagonist for calcium , that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Metabolic Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Tyrosine Hydroxylase | Products > Signaling Pathways > ERK | Products > Signaling Pathways > PKA | Products > Signaling Pathways > Calcium Channel | Products > Signaling Pathways > Cyclic GMP-AMP Synthase

Product Information

Catalog No.: HY-123468
CAS No.: 91742-10-8
Molecular Formula: C12H15N5O2S
Molecular Weight: 293.34
Purity: 99.04%
Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
Solubility: ≥ 1.25 mg/mL (4.26 mM); Clear solution
Availability: In-stock

Source

Original product source

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