Siponimod-d 11

CAS No.：2104759-32-0
Grade：99.98%
Formula：C29H24D11F3N2O3
M.W.：527.66

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

Siponimod -d 11 (BAF-312-d 11 ) is deuterium labeled Siponimod ( HY-12355 ). Siponimod is an orally active, blood-brain barrier penetrant dual agonist of S1P1 / S1P5 , with EC 50 values of 0.39 nM and 0.98 nM, respectively. Siponimod induces S1P1 internalization, activates GIRK channels, inhibits lymphocyte egress, reduces peripheral lymphocyte counts, triggers transient bradycardia, prevents synaptic neurodegeneration, promotes remyelination, alleviates demyelination, and prevents the loss of GABAergic interneurons. Siponimod can be used in research related to multiple sclerosis.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Isotope-Labeled Compounds | Products > Signaling Pathways > Potassium Channel | Products > Signaling Pathways > LPL Receptor

Product Information

Catalog No.: HY-12355S
CAS No.: 2104759-32-0
Molecular Formula: C29H24D11F3N2O3
Molecular Weight: 527.66
Purity: 99.98%
Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
Availability: In-stock

Source

Original product source

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