Satratoxin H is a toxic metabolite of Stachybotrys atra . Satratoxin H induces caspase-3 and PARP cleavage via p38 MAPK and JNK pathways, stimulates JNK , ERK , and p38 MAPK phosphorylation, and activates JNK and p38 MAPK in a glutathione -sensitive manner. Satratoxin H induces DNA double-stranded breaks, apoptotic body formation, intracellular reactive oxygen species generation, and endoplasmic reticulum stress via ATF6 , PERK , and IRE1 pathways. Satratoxin H can be used for the research of central nervous system disorders and melanoma.
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