T-5342126 is a toll-like receptor 4 ( TLR4 ) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells ( IC 50 =27.8 μM), as well as decreases LPS-induced IL-8 , TNF-α, and IL-6 production in isolated human whole blood ( IC 50 s=110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Toll-like Receptor (TLR)
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