THAL-SNS-032

CAS No.：2139287-33-3
Grade：97.11%
Formula：C40H52N8O10S2
M.W.：869.02
Solvent：≥ 2.5 mg/mL (2.88 mM); Clear solution

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

THAL-SNS-032 is a selective CDK9 PROTAC degrader. THAL-SNS-032 recruits CRBN to form a ternary complex with CDK9 , thereby triggering ubiquitination and proteasomal degradation of CDK9 . THAL-SNS-032 also induces the degradation of CDK1 , CDK2 and CDK7 . THAL-SNS-032 elevates pH2AX levels, reduces MCL1s expression, and activates caspase-3 . THAL-SNS-032 induces cancer cell apoptosis , regulates transcription, and inhibits the replication of human cytomegalovirus ( CMV ) and SARS-CoV-2 . THAL-SNS-032 can be used in research related to breast cancer , leukemia, cytomegalovirus infection and SARS-CoV-2 infection . (Pink: CDK9 ligand ( HY-10008 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker ( HY-W015088 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Viral Infection | Products > Disease Areas > Coronavirus Infection | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Cytomegalovirus Infection | Products > Disease Areas > SARS-CoV-2 Infection | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > SARS-CoV | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > CMV

Product Information

Catalog No.: HY-123937
CAS No.: 2139287-33-3
Molecular Formula: C40H52N8O10S2
Molecular Weight: 869.02
Purity: 97.11%
Storage: -20°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solubility: ≥ 2.5 mg/mL (2.88 mM); Clear solution
Availability: In-stock

Source

Original product source

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