FKBP12 PROTAC dTAG-7

Overview

FKBP12 PROTAC dTAG-7 (dTAG-7) is a FKBP12 F36V PROTAC degrader. FKBP12 PROTAC dTAG-7 binds FKBP12 F36V and CRBN to form a complex, mediating degradation via the ubiquitin-proteasome system. FKBP12 PROTAC dTAG-7 mediates the degradation of FKBP12 F36V -tagged nuclear and cytoplasmic proteins, including BRD4 , HDAC1 , EZH2 , MYC , PLK1 , KRAS G12V , and antigen fusion proteins. FKBP12 PROTAC dTAG-7 enhances MHC class I antigen presentation. FKBP12 PROTAC dTAG-7 is applicable to leukemia-related research. (Pink: FKBP12 ligand ( HY-114420 ); Blue: Cereblon ligand ( HY-103597 ); Black: linker ( HY-128844 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > FKBP | Products > Signaling Pathways > Epigenetic Reader Domain | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > Histone Methyltransferase | Products > Signaling Pathways > c-Myc | Products > Signaling Pathways > Polo-like Kinase (PLK) | Products > Signaling Pathways > Ras | Products > Signaling Pathways > MHC

Product Information

• Catalog No.: HY-123941
• CAS No.: 2064175-32-0
• Molecular Formula: C63H79N5O19
• Molecular Weight: 1210.32
• Purity: 99.47%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: 3.75 mg/mL (3.10 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source