3-Ethoxy-5,6-dibromosalicylaldehyde

Overview

3-ethoxy-5,6-dibromosalicylaldehyde is a potent, non-competitive, selective IRE1 (including IRE1α) inhibitor ( IC 50 s: ∼0.12 μM for hIRE1α-cyto; 6 μM for yeast Ire1 ). 3-ethoxy-5,6-dibromosalicylaldehyde inhibits XBP-1 splicing. 3-ethoxy-5,6-dibromosalicylaldehyde induces Apoptosis . 3-ethoxy-5,6-dibromosalicylaldehyde upregulates the mRNA expression level of TXNIP , while downregulating the expression level of TXN . 3-ethoxy-5,6-dibromosalicylaldehyde exhibits anticancer activity against pancreatic cancer . 3-ethoxy-5,6-dibromosalicylaldehyde significantly inhibits chikungunya virus replication.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Viral Infection | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > IRE1 | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Arrestin | Products > Signaling Pathways > CHIKV

Product Information

• Catalog No.: HY-123996
• CAS No.: 20041-64-9
• Molecular Formula: C9H8Br2O3
• Molecular Weight: 323.97
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source