Other grades of this product :
| APRINDINE HCL Basic information |
| Product Name: | APRINDINE HCL | | Synonyms: | fiboran;ms-5075;n-(3-(diethylamino)propyl)-n-phenyl-2-indanaminhydrochloride;n,n-diethyl-n’-2-indanyl-n’-phenyl-1,3-propanediaminehydrochloride;APRINDINE HCL;APRINDINE HYDROCHLORIDE;N-(2,3-dihydro-1H-inden-2-yl)-N',N'-diethyl-N-phenylpropane-1,3-diamine monohydrochloride;Amidonal | | CAS: | 33237-74-0 | | MF: | C22H31ClN2 | | MW: | 358.95 | | EINECS: | 251-418-7 | | Product Categories: | pharmacetical | | Mol File: | 33237-74-0.mol |
| APRINDINE HCL Chemical Properties |
| Melting point | 120-121° | | storage temp. | 2-8°C | | solubility | H2O: >10mg/mL | | form | solid | | color | Light Brown to Brown |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 | | RTECS | TX7386000 |
| APRINDINE HCL Usage And Synthesis |
| Originator | Amidonal,Madaus,W. Germany,1976 | | Uses | Aprindine is a long-acting antiarrhythmic agent, effective when administered orally or intravenously in the treatment of ventricular arrhythmias of varying etiologies. | | Manufacturing Process | 104.6 g (0.5 mol) N-phenyl-2-aminoindane and 2.5 liters benzene are
introduced into a reaction vessel of 5 liters, under an atmosphere of nitrogen.
37 g (0.95 mol) sodium amide are added and the mixture is stirred during 3
hours at room temperature.
119.7 g (0.8 mol) of γ-chloropropyl diethylamine are then quickly added. After
agitation during 1 hour at room temperature, the reaction mixture is refluxed
and stirred under nitrogen during 21 hours. The mixture is then allowed to
cool and poured onto ice. The obtained aqueous phase is extracted by means
of 500 cm3 of benzene. The benzene extract is washed two times with 200
cm3 of water and the benzene is then evaporated.
The residue is treated with 500 cm3 of hydrochloric acid (2 N). The obtained
solution is evaporated to dryness and the oily residue is recrystallized from
ethanol. 176.9 g (yield 89.4%) of dihydrochloride of N-phenyl-Ndiethylaminopropyl-
2-aminoindane are obtained, MP 208° to 210°C.
The dihydrochloride is converted into monohydrochloride by dissolving 26.36 g
(0.066 mol) of dihydrochloride into 158 cm3 of water, adding drop by drop a
suitable amount (0.066 mol) of caustic soda (1 N), evaporating the aqueous
solution to dryness, drying by means of benzene, filtering the formed sodium
chloride (3.8 g) and crystallizing the cooled obtained benzene solution. 22.6 g
(95%) of monohydrochloride are obtained, MP 120° to 121°C. | | Brand name | Fibocil (Lilly). | | Therapeutic Function | Antiarrhythmic |
| APRINDINE HCL Preparation Products And Raw materials |
|
日本语
한국어
Français
Deutsch
España
Türkiye