BAY-8040 is a pyrimidopyridazine derivative which has inhibitory activity against human neutrophil elastase ( HNE ). BAY-8040 decreases cardiac remodeling and ameliorates cardiac function in a Monocrotaline ( HY-N0750 )-induced rat model for pulmonary arterial hypertension. BAY-8040 is promising for research of inflammatory pathologies and cardiopulmonary pathologies.
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