8-Deazahomofolic acid is an inhibitor of thymidylate synthase (TS) and other folate-related enzymes . 8-Deazahomofolic acid shows inhibitory activity against folate-dependent S. faecium, L. casei, and MTX ( HY-14519 ) resistant strains. 8-Deazahomofolic acid also inhibits the growth of L1210 leukemia cells, with an IC 50 value of 87.5 μM. 8-Deazahomofolic acid can be used in research on bacterial infections and tumors.
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