Eicosatetraynoic acid

Overview

Eicosatetraynoic acid (ETYA) is a non-metabolizable analog of Arachidonic acid ( HY-109590 ) and also an inhibitor of the lipoxygenase ( LOX )/cyclooxygenase ( COX ) pathway ( ID 50 = 8 μM and 4 μM). Eicosatetraynoic acid acts as a suicide substrate to inhibit the production of inflammatory mediators such as leukotrienes and prostaglandins. Eicosatetraynoic acid acts directly on cell membranes and membrane proteins to exert a wide range of effects, including blocking potassium channels, increasing cell membrane fluidity, elevating intracellular calcium levels, inhibiting DNA synthesis in tumor cells, inducing differentiation of certain cells, and specifically inhibiting the assembly and replication of orthopoxviruses. Eicosatetraynoic acid alleviates acute lung injury induced by chemicals such as phosgene.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Viral Infection | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Respiratory Inflammation | Products > Disease Areas > Orthopoxvirus Infection | Products > Disease Areas > Acute Lung Injury | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Others | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Orthopoxvirus | Products > Signaling Pathways > Potassium Channel | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Drug Derivative | Products > Signaling Pathways > COX | Products > Signaling Pathways > Lipoxygenase

Product Information

• Catalog No.: HY-124108
• CAS No.: 1191-85-1
• Molecular Formula: C20H24O2
• Molecular Weight: 296.40
• Purity: 99.9%
• Storage: Powder -20°C, 3 years * The compound is unstable in solutions, freshly prepared is recommended.
• Availability: In-stock

Source

Original product source