N-Octadecyl-N'-propyl-sulfamide

Overview

Peroxisome proliferator-activated receptors (PPARs) play an important role in regulating lipid and glucose metabolism, and oleoylethanolamide (OEA) is a natural ligand for PPARα . N-Octadecyl-N'-propyl-sulfamide is an analog of OEA and a potent activator of PPARα , with selective binding affinity for PPARα (EC50=100 nM, compared to 120 nM for OEA). N-Octadecyl-N'-propyl-sulfamide (10 mg/kg; ip ) inhibits food intake and reduces body weight gain in rats. At a dose of 1 mg/kg, N-Octadecyl-N'-propyl-sulfamide induces satiety, thereby reducing food intake, body weight, and plasma triglyceride concentrations in free-feeding Wistar rats and obese Zucker (fa/fa) rats.

Application

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Product Information

• Catalog No.: HY-124399
• CAS No.: 925891-74-3
• Molecular Formula: C21H46N2O2S
• Molecular Weight: 390.67
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source