IHVR-19029 is a potent endoplasmic reticulum (ER) α-glucosidases I and II inhibitor, with an IC 50 of 0.48 μM for ER a-glucosidase I. IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Dengue virus (DENV), Ebola virus ( EBOV ) and Rift Valley fever virus. The combination of IHVR-19029 with Favipiravir ( HY-14768 ) improves the antiviral efficacy.
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