DS86760016 is a potent leucyl-tRNA synthetase (LeuRS) inhibitor with activity against multidrug-resistant (MDR) Gram-negative bacteria, such as Escherichia coli , Klebsiella pneumoniae , and Pseudomonas aeruginosa . DS86760016 inhibits LeuRS enzymes from Escherichia coli , Pseudomonas aeruginosa , and Acinetobacter baumannii , with IC 50 s of 0.38, 0.62, and 0.16 μM, respectively.
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