Filastatin is a long-lasting inhibitor of Candida albicans filamentation . Filastatin inhibits adhesion by multiple pathogenic Candida species with an IC 50 of ~3 μM in the GFP-based adhesion assay. Filastatin inhibits fungal adhesion to polystyrene and human cells, the yeast-to-hyphal morphological transition, induction of the hyphal-specific HWP1 promoter. Filastatin has potent antifungal effect.
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