GMB-475

Overview

GMB-475 is a potent BCR-ABL1 PROTAC based on Von Hippel-Lindau (VHL) . GMB-475 targets the nutmeg pocket of ABL1 in an ectopic manner and degrades BCR-ABL1 protein through the ubiquitin proteasome pathway. GMB-475 inhibits the proliferation of human K562 cells and mouse Ba/F3 cells, and is used for the study of chronic myeloid leukemia. (Pink: BCR-ABL1 ligand ( HY-11007 ); Blue: VHL ligand ( HY-125845 ); Black: linker).

Application

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Product Information

• Catalog No.: HY-125834
• CAS No.: 2490599-18-1
• Molecular Formula: C43H46F3N7O7S
• Molecular Weight: 861.93
• Purity: 98.69%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 6.25 mg/mL (7.25 mM); Clear solution
• Availability: In-stock

Source

Original product source