A-9758

Overview

A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist ( IC 50 =5 nM), and exhibits robust potency against IL-17A release. A-9758 is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis and is effective in blocking skin and joint inflammation.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > ROR | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-126252
• CAS No.: 2055271-22-0
• Molecular Formula: C25H23Cl2F3N2O3
• Molecular Weight: 527.36
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source