DMT1 blocker 1

Overview

DMT1 blocker 1 is an orally active blocker of divalent metal transporter 1 ( DMT1 ) with an IC 50 of 0.64 μM. DMT1 blocker 1 inhibits intestinal cell absorption of non-heme iron, thereby alleviating iron overload by blocking the DMT1 transporter. DMT1 blocker 1 demonstrates significant efficacy in rodent models of acute iron hyperabsorption. DMT1 blocker 1 is useful for studying iron overload disorders such as hereditary hemochromatosis and thalassemia.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Ferroportin

Product Information

• Catalog No.: HY-126301
• CAS No.: 1354790-56-9
• Molecular Formula: C16H14N4O2
• Molecular Weight: 294.31
• Purity: 99.71%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 0.83 mg/mL (2.82 mM); Clear solution
• Availability: In-stock

Source

Original product source