TCMDC-135051 TFA is a highly selective and potent protein kinase Pf CLK3 inhibitor with low off-target toxicity. TCMDC-135051 TFA prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 TFA has antiparasiticidal activity (EC 50 =320 nM).
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