Kansuinine A

Overview

Kansuinine A is a diterpenoid compound. Kansuinine A is isolated from the roots of Euphorbia kansui . Kansuinine A inhibits H 2 O 2 -mediated upregulation of phosphorylated IKKβ , NF-κB and IκBα . Kansuinine A inhibits ROS production, reduces the Bax/Bcl-2 ratio and the expression of cleaved Caspase-3 . Kansuinine A upregulates the expression of SOCS-3 and blocks IL-6 -induced signal transduction. Kansuinine A decreases the expression of LOX-1 and inhibits Apoptosis . Kansuinine A reduces the atherosclerotic lesion area of the aortic arch, improves glucose/insulin tolerance, and enhances antioxidant capacity. Kansuinine A exhibits antiviral and antitumor activities. Kansuinine A can be used in research related to atherosclerosis, liver cancer and type 2 diabetes.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Chronic Disease and Inflammation | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Viral Infection | Products > Disease Areas > Atherosclerosis and Inflammation | Products > Disease Areas > Type 2 Diabetes | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > LOX-1 | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > IKK | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

• Catalog No.: HY-126421
• CAS No.: 57701-86-7
• Molecular Formula: C37H46O15
• Molecular Weight: 730.75
• Purity: 99.81%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (3.42 mM); Clear solution
• Availability: In-stock

Source

Original product source