LX7101 monohydrochloride

CAS No.：2319882-48-7
Grade：99.98%
Formula：C23H30ClN7O3
M.W.：487.98

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

LX7101 monohydrochloride is a potent LIM-kinase , ROCK and PKA inhibitor with IC 50 s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1 , LIMK2 , ROCK2 and PKA , respectively. LX7101 monohydrochloride proves significantly selective for LIMK2 with IC 50 values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 monohydrochloride has the potential for ocular hypertension and associated glaucoma research.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Cytoskeleton | Products > Research Areas > Endocrinology | Products > Signaling Pathways > LIM Kinase (LIMK) | Products > Signaling Pathways > ROCK | Products > Signaling Pathways > PKA

Product Information

Catalog No.: HY-12659B
CAS No.: 2319882-48-7
Molecular Formula: C23H30ClN7O3
Molecular Weight: 487.98
Purity: 99.98%
Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source

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