Saquayamycin D is an antibiotic , which can be isolated from Streptomyces nodosus culture broth. Saquayamycin D exhibits antibacterial activity against various gram-positive bacteria with MIC of 12.5-50 μg/mL. Saquayamycin D inhibits the proliferation of Doxorubicin ( HY-15142 )-sensitive P388/S and Doxorubicin-resistant P388/ADR with IC 50 of 0.15 and 0.15 μg/mL.
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