PRN694

Overview

PRN694 is an irreversible, highly selective and potent covalent interleukin-2-inducible T-cell kinase ( ITK ) and resting lymphocyte kinase (RLK) dual inhibitor with IC 50 s of 0.3 nM and 1.4 nM, respectively. PRN694 exhibits extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo .

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Itk

Product Information

• Catalog No.: HY-12680
• CAS No.: 1575818-46-0
• Molecular Formula: C28H35F2N5O2S
• Molecular Weight: 543.67
• Purity: ≥99.0%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.08 mg/mL (3.83 mM); Clear solution
• Availability: In-stock

Source

Original product source