Cholic acid 7-sulfate-d 4

Overview

Cholic acid 7-sulfate -d 4 (7-Sulfocholic acid-d 4 ) is the deuterium labeled Cholic acid 7-sulfate ( HY-126855 ). Cholic acid 7-sulfate is a selective agonist targeting TGR5 (EC 50 =0.17 μM) and a ligand for MHC class I-related protein (MR1). As a gut-restricted TGR5 agonist, cholic acid 7-sulfate binds to TGR5 on enteroendocrine L cells, induces GLP-1 secretion, and improves glucose tolerance in a TGR5-dependent manner. Cholic acid 7-sulfate also acts as an endogenous ligand for MR1, promoting the survival of mucosal-associated invariant T cells MAIT and the expression of homeostatic gene signatures, affecting MAIT cell development and function. Cholic acid 7-sulfate is mainly used in the research of diabetes and MAIT cell-related immune regulation.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Others | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Isotope-Labeled Compounds | Products > Signaling Pathways > G protein-coupled Bile Acid Receptor 1 | Products > Signaling Pathways > MHC

Product Information

• Catalog No.: HY-126855S
• CAS No.: 1332881-66-9
• Molecular Formula: C24H36D4O8S
• Molecular Weight: 492.66
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source