ML324 is a potent JMJD2 demethylase inhibitor with antiviral activity. ML324 also exhibits inhibition for the histone demethylase KDM4B , with an IC 50 of 4.9 μM. ML324 has potent anti-viral activity against both herpes simplex virus ( HSV ) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression.
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