Cycloguanil-d 6 (hydrochloride)

Overview

Cycloguanil-d 6 (Chlorguanide triazine-d 6 ) hydrochloride is the deuterium labeled Cycloguanil hydrochloride ( HY-12784A ). Cycloguanil hydrochloride is a dihydrofolate reductase ( DHFR ) inhibitor with an IC 50 of 10.8 μM against human DHFR . Cycloguanil hydrochloride blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil hydrochloride inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil hydrochloride also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3 , thereby exhibiting anticancer activity.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Others | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Antifolate | Products > Signaling Pathways > Parasite | Products > Signaling Pathways > Isotope-Labeled Compounds | Products > Signaling Pathways > STAT | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-12784AS1
• CAS No.: 2712364-69-5
• Molecular Formula: C11H9D6Cl2N5
• Molecular Weight: 294.21
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source