ML121 is a selective and potent VIM-2 inhibitor with an IC 50 of 54 nM and a K i of 148 nM. ML121 shows inactive in IMP-1 and TEM-1 beta-lactamase assays. ML121 can potentiate the antibiotic activity of Imipenem ( HY-B1369A ) in VIM-2 transformed E.coli .
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