5-(N,N-Hexamethylene)-amiloride

Overview

5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na + /H + exchanger inhibitor, which decreases the intracellular pH (pH i ) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC 50 s of 3.91 μM and 1.34 μM, respectively.

Application

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Product Information

• Catalog No.: HY-128067
• CAS No.: 1428-95-1
• Molecular Formula: C12H18ClN7O
• Molecular Weight: 311.77
• Purity: 99.14%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: 2.08 mg/mL (6.67 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source