Pseudomonas quinolone signal (PQS) is a quorum-sensing signaling molecule produced by Pseudomonas aeruginosa . The synthesis of Pseudomonas quinolone signal relies on the las quorum-sensing system, and its biological activity is associated with the rhl system. Pseudomonas quinolone signal regulates the expression of the virulence gene lasB . Additionally, Pseudomonas quinolone signal plays roles in iron acquisition, cytotoxicity, outer-membrane vesicle biogenesis, and host immune modulation.
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