Complement C5-IN-1

Overview

Compound C5-IN-1 (Compound 7) is a selective allosteric inhibitor of complement component protein C5 . Compound C5-IN-1 prevents C5 from being cleaved by C5 convertase, inhibits the cleavage of C5 into C5a and C5b, and thus blocks the formation of membrane attack complex (MAC) . Compound C5-IN-1 has an IC 50 of 0.77 μM and 5 nM in 50% human whole blood and 2% human serum to block MAC deposition induced by zymosan, respectively. Compound C5-IN-1 can be used to study diseases related to complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Complement System

Product Information

• Catalog No.: HY-128342
• CAS No.: 2365402-67-9
• Molecular Formula: C24H32N2O6
• Molecular Weight: 444.52
• Purity: 99.13%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.62 mM); Clear solution
• Availability: In-stock

Source

Original product source