Enterobactin is a siderophore produced by Gram-negative bacteria and has an extremely high affinity for iron . During the process of Salmonella typhimurium infecting macrophages, Enterobactin can not only help bacteria uptake iron but also reduce the antibacterial activity of macrophages. In addition, Enterobactin is also involved in the oxidative stress response of Escherichia coli . Enterobactin can be hydrolyzed by Fes in the cell and exert antioxidant effects by scavenging free radicals.
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