Gozanertinib is an orally active furanopyrimidine-based EGFR inhibitor with IC 50 s of 15 nM and 48 nM for EGFR WT and EGFR L858R/T790M , respectively. Gozanertinib can occupy the ATP-binding site. Gozanertinib has significant antitumor efficacy.
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