PROTAC MDM2 Degrader-1

Overview

PROTAC MDM2 Degrader-1 (Compound 15a) is a MDM2 PROTAC degrader. The structures of both Linker ends of PROTAC MDM2 Degrader-1 are MDM2 ligands. PROTAC MDM2 Degrader-1 can not only block the binding of p53-MDM2, but also degrade the target MDM2 protein by utilizing the function of the E3 ligase of MDM2 itself, thus exerting an anti-tumor effect. (Pink: MDM2 ligand ( HY-128836 ); Blue: MDM2 ligand ( HY-128836 ); Black: linker ( HY-128844 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > MDM-2/p53

Product Information

• Catalog No.: HY-128840
• CAS No.: 2249944-98-5
• Molecular Formula: C74H84Cl4N10O13
• Molecular Weight: 1463.33
• Purity: 98.11%
• Storage: -20°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: ≥ 0.62 mg/mL (0.42 mM); Clear solution
• Availability: In-stock

Source

Original product source