PROTAC MDM2 Degrader-1

CAS No.：2249944-98-5
Grade：98.11%
Formula：C74H84Cl4N10O13
M.W.：1463.33
Solvent：≥ 0.62 mg/mL (0.42 mM); Clear solution

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Overview

PROTAC MDM2 Degrader-1 (Compound 15a) is a MDM2 PROTAC degrader. The structures of both Linker ends of PROTAC MDM2 Degrader-1 are MDM2 ligands. PROTAC MDM2 Degrader-1 can not only block the binding of p53-MDM2, but also degrade the target MDM2 protein by utilizing the function of the E3 ligase of MDM2 itself, thus exerting an anti-tumor effect. (Pink: MDM2 ligand ( HY-128836 ); Blue: MDM2 ligand ( HY-128836 ); Black: linker ( HY-128844 )).

Application

Product Information

Catalog No.: HY-128840
CAS No.: 2249944-98-5
Molecular Formula: C74H84Cl4N10O13
Molecular Weight: 1463.33
Purity: 98.11%
Storage: -20°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solubility: ≥ 0.62 mg/mL (0.42 mM); Clear solution
Availability: In-stock

Source

Original product source

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