Deoxypheganomycin D is a specific antimycobacterial inhibitor with no cross-resistance to other antibiotics such as Paromomycin ( HY-B0956 ), Capreomycin ( HY-P3270 ), Viomycin ( HY-A0155 ), Streptothricin ( HY-129065 ), Kanamycin ( HY-16566 ), and Streptomycin ( HY-B1906 ). Deoxypheganomycin D (28 μM) partially inhibits the growth of Mycobacterium 607, with no significant inhibitory effects on DNA, RNA, or protein synthesis. Deoxypheganomycin D (7 μM) affects leucine influx, not thymidine, and has the opposite effect on efflux. The effects of Deoxypheganomycin D may be related to cell membrane and specific mycobacterial lipid components.
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