Seco-Duocarmycin SA is a DNA alkylator . Seco-Duocarmycin SA is an antitumor antibiotic ( IC 50 = 10 pM). Seco-Duocarmycin SA can induce a concentration-dependent increase in apoptotic cell death . Seco-Duocarmycin SA can lead to significant cell cycle arrest in S and G2/M phases. Seco-Duocarmycin SA acts as an ADC cytotoxin for antibody-drug conjugates .
Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Antibody-Drug Conjugate/ADC Related | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Antibiotic | Products > Signaling Pathways > ADC Payloads | Products > Signaling Pathways > DNA Alkylator/Crosslinker | Products > Signaling Pathways > Apoptosis
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