KB02-SLF

Overview

KB02-SLF is a nuclear FKBP12 covalent PROTAC degrader. KB02-SLF covalently modifies cysteine residues in DCAF16 , forms a ternary complex with nuclear FKBP12 , and mediates degradation via the CUL4-DDB1 E3 ubiquitin ligase pathway. KB02-SLF promotes polyubiquitination and proteasomal degradation of nucleus-localized FKBP12 . KB02-SLF can be used in breast cancer research. (Pink: FKBP12 ligand ( HY-114872 ); Blue: Cereblon ligand ( HY-131385 ); Black: linker ( HY-42149 )).

Application

Products | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > FKBP

Product Information

• Catalog No.: HY-129610
• CAS No.: 2384184-40-9
• Molecular Formula: C50H65ClN4O12
• Molecular Weight: 949.52
• Purity: 99.25%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: 5 mg/mL (5.27 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source