Mavelertinib is a selective, orally available and irreversible EGFR tyrosine kinase inhibitor ( EGFR TKI) , with IC 50 s of 5, 4, 12 and 3 nM for Del, L858R, and double mutants T790M/L858R and T790M/Del, respectively. Mavelertinib can be used for the research of non-small-cell lung cancer (NSCLC).
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