Piperafizine B exhibits slightly cytotoxicity in moser cells, P388 cells and Vincristine (VCR) ( HY-N0488 )-resistant P388 cells ( IC 50 s is 23.8, 22.6 and 23.7 μg/mL, respectively). Piperafizine B exhibits synergistic effects with Vincristine, enhances the VCR-induced cytotoxicity and ameliorates the leukemia in mouse model.
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