Luzopeptin A (BBM-928 A) is an actinoleukin-like antitumor antibiotic . Luzopeptin A is a bifunctional DNA intercalator which can interact with isolated DNA molecules. Luzopeptin A induces an unwinding-rewinding process of the closed superhelical PM2 DNA. Luzopeptin A is active against HIV-1 and HIV-2 reverse transcriptase with IC 50 s of 7 nM and 68 nM for HIV-1 RT and HIV-2 RT, respectively.
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